What is LUMAKRAS®?

LUMAKRAS® is a prescription medicine used to treat adults with non-small cell lung cancer (NSCLC) that has spread to other parts of the body or cannot be removed by surgery, and whose tumor has an abnormal KRAS G12C gene, and who have received at least one prior treatment for their cancer.

Your healthcare provider will perform a test to make sure that LUMAKRAS® is right for you. It is not known if LUMAKRAS® is safe and effective in children.

For US Audiences Only Approved Use Patient Information Full Prescribing Information Important Safety Information Select Cancer Type For Health Care Professionals

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If you have private or commercial insurance that you get from your employer or buy directly from a health insurance company, you may be eligible to pay as little as $0 for your prescription.

The Amgen SupportPlus Co-Pay Program may help patients with private or commercial insurance lower their out-of-pocket costs

  • Pay as little as $0* out-of-pocket for each dose
  • Can be applied to deductible, co-insurance, and co-payment*
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*Amgen Nurse Partners are only available to patients that are prescribed certain Amgen products. They are not part of your treatment team and do not provide medical advice, nursing, or case management services. Amgen Nurse Partners will not inject patients with Amgen medications. Patients should always consult their healthcare provider regarding medical decisions or treatment concerns.

Where can I get LUMAKRAS®?

There are multiple ways to receive your LUMAKRAS®. Talk to your doctor about your options

LUMAKRAS® may be available through a specialty pharmacy. Specialty pharmacies provide medicines for rare or complex illnesses. Your doctor can help you find a specialty pharmacy that works with your insurance

Working with a specialty pharmacy: Once your insurance coverage has been verified, the specialty pharmacy will contact you to set up delivery of your prescription

Specialty pharmacy providers may be able to help you with the following:1

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Fill your prescription and coordinate home delivery

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Help you navigate your insurance coverage

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Connect you
to additional
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Answer questions about paying for your treatment

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For more information, download the Patient Access Roadmap

Download Patient Access Roadmap
patient-testimonial-image
Find your people. So it’s like a family. You know, somebody says we’re all on the same ocean, we just have a different boat.”

– Laurie S.
current LUMAKRAS® patient

Patient story represents individual’s experience with LUMAKRAS®. Results may vary.

How can I connect with others with NSCLC?

There are many lung cancer organizations and patient communities that can provide you with useful information and offer you and your caregiver much-needed support. We've included a few examples of independent, nonprofit organizations that may be able to help people with NSCLC

Please note that the following advocacy organizations don't endorse any specific cancer treatments. You should talk with your doctors about what treatment is right for you

Connect with communities to help you stay informed and supported

These websites are being shared for informational purposes only; they do not constitute an endorsement by Amgen of any products, services, or opinions of the organization or individual. Amgen bears no responsibility for the accuracy, legality, or content of these external sites.

LungevityLungevity
lung-cancerlung-cancer
cancer support cummunitycancer support cummunity
Kras KickersKras Kickers

Important Safety Information

What should I tell my healthcare provider before taking LUMAKRAS®?

  • Before taking LUMAKRAS®, tell your healthcare provider about all your medical conditions, including if you:
    • have liver problems.
    • have lung or breathing problems other than lung cancer.
    • are pregnant or plan to become pregnant. It is not known if LUMAKRAS® will harm your unborn baby.
    • are breastfeeding or plan to breastfeed. It is not known if LUMAKRAS® passes into your breast milk. Do not breastfeed during treatment with LUMAKRAS® and for 1 week after the final dose.
  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary and herbal supplements. LUMAKRAS® can affect the way some other medicines work, and some other medicines can affect the way LUMAKRAS® works.
  • Especially tell your healthcare provider if you take antacid medicines, including Proton Pump Inhibitor (PPI) medicines or H2 blockers during treatment with LUMAKRAS®. Ask your healthcare provider if you are not sure.

LUMAKRAS® may cause serious side effects, including:

  • Liver Problems: LUMAKRAS® may cause abnormal liver blood test results. Your healthcare provider should do blood tests before starting and during treatment with LUMAKRAS® to check liver function. Tell your healthcare provider right away if you get any signs or symptoms of liver problems, including: your skin or the white part of your eyes turns yellow (jaundice), dark or “tea-colored” urine, light-colored stools (bowel movements), tiredness or weakness, nausea or vomiting, bleeding or bruising, loss of appetite, and pain, aching, or tenderness on the right side of your stomach-area (abdomen).
  • Lung or breathing problems: LUMAKRAS® may cause inflammation of the lungs that can lead to death. Tell your healthcare provider or get emergency medical help right away if you have new or worsening shortness of breath, cough, or fever.
  • Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with LUMAKRAS® if you develop side effects.

The most common side effects

  • The most common side effects of LUMAKRAS® include diarrhea, muscle or bone pain, nausea, tiredness, liver problems, cough, changes in liver function tests, and changes in certain blood tests.
  • These are not all the possible side effects of LUMAKRAS®. Call your doctor for medical advice about side effects.

What is LUMAKRAS®?

LUMAKRAS® is a prescription medicine used to treat adults with non-small cell lung cancer (NSCLC) that has spread to other parts of the body or cannot be removed by surgery, and whose tumor has an abnormal KRAS G12C gene, and who have received at least one prior treatment for their cancer. Your healthcare provider will perform a test to make sure that LUMAKRAS® is right for you. It is not known if LUMAKRAS® is safe and effective in children.

Please see LUMAKRAS® full Prescribing Information.

References: 1. NCI Dictionary of Cancer Terms. www.cancer.gov. Accessed January 27, 2025. 2. LUMAKRAS® (sotorasib) prescribing information, Amgen. 3. Ryan MB, et al. Nat Rev Clin Oncol. 2018;15:709-720. 4. Hong DS, et al. N Engl J Med. 2020;383:1207-1217. 5. Data on file, Amgen; [Analysis of AACR Genie v12].

References: 1. Hong DS, et al. N Engl J Med. 2020;383:1207-1217. 2. NCI Dictionary of Cancer Terms. www.cancer.gov. Accessed January 27, 2025. 3. LUMAKRAS® (sotorasib) prescribing information, Amgen. 4. Sotorasib CSR. Amgen; 2021. 5. Data on file, Amgen; [KRAS G12C Trials Sites]. 6. LUMAKRAS® (sotorasib) patient information, Amgen.

References: 1. LUMAKRAS® (sotorasib) patient information, Amgen. 2. LUMAKRAS® (sotorasib) prescribing information, Amgen. 3. Data on file, Amgen; [Sotorasib Tablet Size].

Important Safety Information

What should I tell my healthcare provider before taking LUMAKRAS®?

  • Before taking LUMAKRAS®, tell your healthcare provider about all your medical conditions, including if you:
    • have liver problems.
    • have lung or breathing problems other than lung cancer.