SIDE EFFECTS

WHAT SHOULD I DO IF...

I forget or am unable to take LUMAKRAS™ at my usual time?

If you miss a dose of LUMAKRAS™, take the dose as soon as you remember. If it has been more than 6 hours, do not take the dose. Take your next dose at your regularly scheduled time the next day. Do not take 2 doses at the same time to make up for a missed dose.1

I vomited shortly after taking LUMAKRAS™?

If you vomit after taking a dose of LUMAKRAS™, do not take an extra dose. Take your next dose at your regular scheduled time the next day.1

I take an antacid?

If you take an antacid medicine, take LUMAKRAS™ either 4 hours before or 10 hours after the antacid.1

I’m prescribed other medications?

Before taking LUMAKRAS™, tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary and herbal supplements. LUMAKRAS™ can affect the way some other medicines work, and some other medicines can affect the way LUMAKRAS™ works.1

WHAT ARE THE POTENTIAL SIDE EFFECTS?

When taking any medication, it’s important to be aware of any side effects that you may experience.
Talk to your healthcare provider immediately if you notice any side effects so they can make the appropriate decision about further treatment.2

Some of the most common side effects include1:

  • Diarrhea

  • Muscle or bone pain

  • Nausea

  • Tiredness

  • Liver problems

  • Cough

  • Changes in liver function test and changes in certain other blood tests

These are not all the possible side effects of LUMAKRAS™. Call your doctor for medical advice about side effects.

LUMAKRAS™ may cause serious side effects, including1:

  • Liver problems. LUMAKRAS™ may cause abnormal liver blood test results. Your healthcare provider should do blood tests before starting and during treatment with LUMAKRAS™ to check your liver function. Tell your healthcare provider right away if you get any signs or symptoms of liver problems, including your skin or the white part of your eyes turns yellow (jaundice), dark or “tea-colored” urine, light-colored stools (bowel movements), tiredness or weakness, nausea or vomiting, bleeding or bruising, loss of appetite, and pain, aching, or tenderness on the right side of your stomach-area (abdomen).

  • Lung or breathing problems. LUMAKRAS™ may cause inflammation of the lungs that can lead to death. Tell your healthcare provider or get emergency medical help right away if you have new or worsening shortness of breath, cough or fever.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with LUMAKRAS™ if you develop side effects.