ABOUT LUMAKRAS™ (SOTORASIB)

WHAT IS LUMAKRAS™
AND HOW DOES IT WORK?

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LUMAKRAS™ is a once-daily oral prescription medicine used to treat adults living with non-small cell lung cancer (NSCLC) that has spread to other parts of the body or cannot be removed by surgery, and whose tumor has an abnormal KRAS G12C gene, and who have received at least one prior treatment for their cancer.1

If your cancer has progressed on a prior therapy like chemotherapy or immunotherapy, LUMAKRAS™ may be able to help.2

LUMAKRAS™ is designed to target KRAS G12C to potentially stop the rapid growth of cancer cells and may shrink tumors.2

Clinical Trial Results

In a clinical trial, 126 adults were given an oral treatment called LUMAKRAS™. The trial evaluated how many adults responded to LUMAKRAS™, meaning their tumors either shrank or disappeared. The trial also measured how long the tumor responded to LUMAKRAS™.2

36%*

of people saw their tumor shrink at least 30% or disappear with LUMAKRAS™.2-4

* 36% is based on 45 people which include 2 people who saw their tumor completely disappear and 43 people who saw their tumor shrink partially.3

81%*

LUMAKRAS™ shrank tumors and/or suppressed tumor growth in 81%
of people.3

*81% is based on 100 people, of which 2 people saw their tumor disappear, 43 people saw their tumor shrink partially, and 55 people saw their tumor remain stable.3

Important considerations: The approval of LUMAKRAS™ in these patients is based on a study that measured the size of tumor shrinkage. Talk to your doctor to see if LUMAKRAS™ is right for you.

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Ask your doctor if LUMAKRAS
is right for you.

HOW SHOULD I TAKE LUMAKRAS?

1xdaily

Take LUMAKRASTM once daily by mouth with or without food.1

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The recommended dose of LUMAKRAS™ is 960 mg (eight 120 mg tablets)
taken orally once daily.1,2

  • Take LUMAKRAS™ exactly as your healthcare provider tells you to take it. Do not change your dose or stop taking LUMAKRAS™ unless your healthcare provider tells you to.

  • Take LUMAKRAS™ 1 time each day, at about the same time each day.

swallow

Swallow LUMAKRAS™ tablets whole. Do not chew, crush, or split tablets.
If you cannot swallow LUMAKRAS™ tablets whole1:

  • Place your daily dose of LUMAKRAS™ in a glass of 4 ounces (120 mL) of non‑carbonated, room temperature water without crushing the tablets. Do not use any other liquids.

  • Stir until the tablets are in small pieces (the tablets will not completely dissolve). The color of the mixture may be pale yellow to bright yellow.

  • Drink the LUMAKRAS™ and water mixture right away or within 2 hours of preparing. Do not chew pieces of the tablet.

  • Rinse the glass with an additional 4 ounces (120 mL) of water and drink to make sure that you have taken the full dose of LUMAKRAS™.

  • If you do not drink the mixture right away, stir the mixture again before drinking.